A new injectable granular filler could be a “major breakthrough” in diabetes wound care and management, a recent study has indicated.
Latest research conducted at the Terasaki Institute for Biomedical Innovation and the University of Nebraska Medical Center has found that specialised porous dermal fillers can speed up tissue healing and regeneration.
The technology could significantly improve diabetic wound outcomes by combining electrospinning and electrospraying technologies to create porous, granular nanofibrous microspheres (NMs).
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Made from biocompatible materials including poly (lactic-co-glycolic acid) (PLGA) and gelatin, these microspheres can be easily injected into wound sites.
Senior author Dr Johnson John said: “This technology marks a major breakthrough in wound care and management, impacting millions of patients globally.
“Our approach offers a less invasive, highly advanced approach from current treatments potentially improving healing outcomes in a short period of time.”
The results have shown that dermal fillers with tunable porous microstructures enhanced cell migration and granulation tissue formation, as well as neovascularisation.
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During the minimally invasive injection process, the dermal fillers showed improved strength and maintained their shape.
Corresponding author Dr Ali Khademhosseini said: “This innovative approach to treating diabetic foot ulcers represents exactly the kind of clinically transitional technology we need in modern healthcare.
“By combining advanced biomaterials science with practical clinical applications, we’re opening new possibilities for millions of people with diabetes who suffer from chronic wounds.”
Dr Khademhosseini added: “This research exemplifies our commitment to developing solutions that are both scientifically sophisticated and practically applicable in real-world medical settings.”
Read the study in the journal ACS Nano.
